I’m starting to think the 45-110 is getting too much for me and I should upgrade to a 45-70. It’s an exceptional day when I can keep 10 shots on an 8-inch bull and a rare day when I can keep all 10 within 4 inches. Mike Herth
Although it did not make it to the current issue of Black Powder Cartridge News I did submit an article titled "The Balanced Load" as to some current experiences along the lines Mike is alluding to. And 'NO' there is no little blue pill you can take or give to your rifle that will make it shoot sub minute of angle groups. There are methods, however, you might consider before lamenting further.
A little hint, can you load your 45-110 to 1140-1150 fps using a Saeco #745 cast 1-20 at or slightly above groove diameter for your bore ?
The previous success in the 110 was with Goex Express 2F but you may find either Swiss 1.5 or 2F will work. It will take some experimentation but a lot cheaper than a rebarrel or new rifle.
I know, I know, you have a buffalo gun that will hot rod 530 grain bullets, but, you are not shooting Buffalo, you are shooting paper.